Journal Articles

Check out our peer reviewed results in leading industry journals

Systems biology and in vitro validation identifies family with sequence similarity 129 member A (FAM129A) as an asthma steroid response modulator

February 27, 2018

McGeachie MJ, Clemmer GL, Hayete B, Xing H, Runge K, Wu AC, Jiang X, Lu Q, Church B, Khalil I, Tantisira K, Weiss S. The Journal of allergy and clinical immunology. February 27, 2018. DOI: 10.1016/j.jaci.2017.11.059

Bayesian network inference modeling identifies TRIB1 as a novel regulator of cell cycle progression and survival in cancer cells

January 13, 2017

Gendelman R, Xing H, Mirzoeva OK, Sarde P, Curtis C, Feiler H, McDonagh P, Gray JW, Khalil I, Korn WM. Cancer Research. Cancer Res January 13 2017 DOI: 10.1158/0008-5472.CAN-16-0512.

Clinical and Economic Burden of Commercially Insured Patients with Acromegaly in the United States: A Retrospective Analysis

Decemeber 21, 2015

Hilary Placzek, PhD, MPH; Yaping Xu, MD, MPH; Yunming Mu, PhD; Susan M. Begelman, MD; and Maxine Fisher, PhD, J Managed Care Spec Pharm. 2015;21(12):1106-14

The potential of biologic network models in understanding the etiopathogenesis of ovarian cancer

February 2010

Khalil I, Brewer MA, Neyarapally T, Runowicz CD. Gynecol Oncol. 2010. 116(2):282-5. PMID: 19931138

Achieving confidence in mechanism for drug discovery and development

November 12, 2007

Pitluk Z, Khalil I. Drug Discov Today. 2007. 12(21-22):924-30. PMID: 17993410

Systems biology for cancer

January 17, 2005

Khalil IG, Hill C. Curr Opin Oncol. 2005. 17(1):44-8. PMID: 15608512

Large-scale identification of clinical and genetic predictors of motor progression in patients with newly diagnosed Parkinson’s disease: a longitudinal cohort study and validation

September 25, 2017

Latourelle J, Beste M, Hadzi T, Miller R, Oppenheim J, Valko M, Wuest D, Church B, Khalil I, Hayete, B, Venuto C. Lancet Neurology Online. September 25, 2017. DOI

Inferring Gene Networks for Strains of Dehalococcoides Highlights Conserved Relationships between Genes Encoding Core Catabolic and Cell-Wall Structural Proteins

November 9, 2016

Mansfeldt CB, Heavner GW, Rowe AR, Hayete B, Church BW, Richardson RE (2016) PLoS ONE 11(11): e0166234. doi:10.1371/journal.pone.0166234.

Novel Predictive Models for Metabolic Syndrome Risk- A “Big Data” Analytic Approach

June 1, 2014

Steinberg GB, Church BW, McCall CJ, Scott AB, Kalis BP. Am J Manag Care. 2014. 20(6):e221-e228. PMID: 25180505

Cross-talk between signaling pathways can generate robust oscillations in calcium and cAMP

October 21, 2009

Siso-Nadal F, Fox JJ, Laporte SA, Hébert TE, Swain PS. PLoS One. 2009. 4(10):e7189. PMID: 19844582

A systems biology dynamical model of mammalian G1 cell cycle progression

February 13, 2007

Haberichter T, Mädge B, Christopher RA, Yoshioka N, Dhiman A, Miller R, Gendelman R, Aksenov SV, Khalil IG, Dowdy SF. Mol Syst Biol. 2007. 3:84. PMID: 17299420

The statistical mechanics of complex signaling networks: nerve growth factor signaling

December 1, 2004

Brown KS, Hill CC, Calero GA, Myers CR, Lee KH, Sethna JP, Cerione RA. Phys Biol. 2004. 1(3-4):184-95. PMID: 16204838

A Bayesian mathematical model of motor and cognitive outcomes in Parkinson’s disease

June 12, 2017

Hayete B, Wuest D, Laramie J, McDonagh P, Church B, Eberly S, et al. (2017) PLoS ONE 12(6): e0178982.

Reverse Engineering and Evaluation of Prediction Models for Progression to Type 2 Diabetes: An Application of Machine Learning Using Electronic Health Records

December 20, 2015

Anderson JP, Parikh JR, Shenfeld DK, Ivanov V, Marks C, Church BW, Laramie JM, Mardekian J, Piper BA, Willke RJ, Rublee DA. Journal of Diabetes Science and Technology. 2016. 10(1):6-18. PMID: 26685993

Causal modeling using network ensemble simulations of genetic and gene expression data predicts genes involved in rheumatoid arthritis

March 7, 2011

Xing H, McDonagh PD, Bienkowska J, Cashorali T, Runge K, Miller RE, Decaprio D, Church B, Roubenoff R, Khalil IG, Carulli J. PLoS Comput Biol. 2011. 7(3):e1001105. PMID: 21423713

Customized care 2020: how medical sequencing and network biology will enable personalized medicine

September 28, 2009

Boguski MS, Arnaout R, Hill C. F1000 Biol Rep. 2009. 1:73. PMID: 20948615

An integrated approach for inference and mechanistic modeling for advancing drug development

March 21, 2005

Aksenov SV, Church B, Dhiman A, Georgieva A, Sarangapani R, Helmlinger G, Khalil IG. FEBS Lett. 2005. 579(8):1878-83. PMID: 15763567

Data-driven computer simulation of human cancer cell

May 2004

Christopher R, Dhiman A, Fox J, Gendelman R, Haberitcher T, Kagle D, Spizz G, Khalil IG, Hill C. Ann N Y Acad Sci. 2004. 1020:132-53. PMID: 15208190