Journal Articles
Check out our peer reviewed results in leading industry journals
Systems biology and in vitro validation identifies family with sequence similarity 129 member A (FAM129A) as an asthma steroid response modulator
McGeachie MJ, Clemmer GL, Hayete B, Xing H, Runge K, Wu AC, Jiang X, Lu Q, Church B, Khalil I, Tantisira K, Weiss S. The Journal of allergy and clinical immunology. February 27, 2018. DOI: 10.1016/j.jaci.2017.11.059
Bayesian network inference modeling identifies TRIB1 as a novel regulator of cell cycle progression and survival in cancer cells
Gendelman R, Xing H, Mirzoeva OK, Sarde P, Curtis C, Feiler H, McDonagh P, Gray JW, Khalil I, Korn WM. Cancer Research. Cancer Res January 13 2017 DOI: 10.1158/0008-5472.CAN-16-0512.
Clinical and Economic Burden of Commercially Insured Patients with Acromegaly in the United States: A Retrospective Analysis
Hilary Placzek, PhD, MPH; Yaping Xu, MD, MPH; Yunming Mu, PhD; Susan M. Begelman, MD; and Maxine Fisher, PhD, J Managed Care Spec Pharm. 2015;21(12):1106-14
The potential of biologic network models in understanding the etiopathogenesis of ovarian cancer
Khalil I, Brewer MA, Neyarapally T, Runowicz CD. Gynecol Oncol. 2010. 116(2):282-5. PMID: 19931138
Achieving confidence in mechanism for drug discovery and development
Pitluk Z, Khalil I. Drug Discov Today. 2007. 12(21-22):924-30. PMID: 17993410
Systems biology for cancer
Khalil IG, Hill C. Curr Opin Oncol. 2005. 17(1):44-8. PMID: 15608512
Large-scale identification of clinical and genetic predictors of motor progression in patients with newly diagnosed Parkinson’s disease: a longitudinal cohort study and validation
Latourelle J, Beste M, Hadzi T, Miller R, Oppenheim J, Valko M, Wuest D, Church B, Khalil I, Hayete, B, Venuto C. Lancet Neurology Online. September 25, 2017. DOI http://dx.doi.org/10.1016/S1474-4422(17)30331-9
Inferring Gene Networks for Strains of Dehalococcoides Highlights Conserved Relationships between Genes Encoding Core Catabolic and Cell-Wall Structural Proteins
Mansfeldt CB, Heavner GW, Rowe AR, Hayete B, Church BW, Richardson RE (2016) PLoS ONE 11(11): e0166234. doi:10.1371/journal.pone.0166234.
Novel Predictive Models for Metabolic Syndrome Risk- A “Big Data” Analytic Approach
Steinberg GB, Church BW, McCall CJ, Scott AB, Kalis BP. Am J Manag Care. 2014. 20(6):e221-e228. PMID: 25180505
Cross-talk between signaling pathways can generate robust oscillations in calcium and cAMP
Siso-Nadal F, Fox JJ, Laporte SA, Hébert TE, Swain PS. PLoS One. 2009. 4(10):e7189. PMID: 19844582
A systems biology dynamical model of mammalian G1 cell cycle progression
Haberichter T, Mädge B, Christopher RA, Yoshioka N, Dhiman A, Miller R, Gendelman R, Aksenov SV, Khalil IG, Dowdy SF. Mol Syst Biol. 2007. 3:84. PMID: 17299420
The statistical mechanics of complex signaling networks: nerve growth factor signaling
Brown KS, Hill CC, Calero GA, Myers CR, Lee KH, Sethna JP, Cerione RA. Phys Biol. 2004. 1(3-4):184-95. PMID: 16204838
A Bayesian mathematical model of motor and cognitive outcomes in Parkinson’s disease
Hayete B, Wuest D, Laramie J, McDonagh P, Church B, Eberly S, et al. (2017) PLoS ONE 12(6): e0178982.
Reverse Engineering and Evaluation of Prediction Models for Progression to Type 2 Diabetes: An Application of Machine Learning Using Electronic Health Records
Anderson JP, Parikh JR, Shenfeld DK, Ivanov V, Marks C, Church BW, Laramie JM, Mardekian J, Piper BA, Willke RJ, Rublee DA. Journal of Diabetes Science and Technology. 2016. 10(1):6-18. PMID: 26685993
Causal modeling using network ensemble simulations of genetic and gene expression data predicts genes involved in rheumatoid arthritis
Xing H, McDonagh PD, Bienkowska J, Cashorali T, Runge K, Miller RE, Decaprio D, Church B, Roubenoff R, Khalil IG, Carulli J. PLoS Comput Biol. 2011. 7(3):e1001105. PMID: 21423713
Customized care 2020: how medical sequencing and network biology will enable personalized medicine
Boguski MS, Arnaout R, Hill C. F1000 Biol Rep. 2009. 1:73. PMID: 20948615
An integrated approach for inference and mechanistic modeling for advancing drug development
Aksenov SV, Church B, Dhiman A, Georgieva A, Sarangapani R, Helmlinger G, Khalil IG. FEBS Lett. 2005. 579(8):1878-83. PMID: 15763567
Data-driven computer simulation of human cancer cell
Christopher R, Dhiman A, Fox J, Gendelman R, Haberitcher T, Kagle D, Spizz G, Khalil IG, Hill C. Ann N Y Acad Sci. 2004. 1020:132-53. PMID: 15208190